| Company Name: |
VDM Biochemicals
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0330-2528181 |
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sales@vdmbio.com |
| Products Intro: |
Product Name:VEGFR2 Kinase Inhibitor II
CAS:288144-20-7
Purity:>=95% by HPLC Package:80USD/1mg
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:VEGFR2 Kinase Inhibitor II
CAS:288144-20-7
Purity:95% Package:1G;10G;100G Remarks:VEGFR2 kinase inhibitor II is a reversible and cell-permeable inhibitor of VEGFR2’s kinase activity with IC50 value of 70 nM. It also less potently inhibits the platelet-derived growth factor receptor
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:VEGFR2 Kinase Inhibitor II
CAS:288144-20-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | VEGFR2 Kinase Inhibitor II Basic information |
| Product Name: | VEGFR2 Kinase Inhibitor II | | Synonyms: | VEGFR2 Kinase Inhibitor II;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-;VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II | | CAS: | 288144-20-7 | | MF: | C17H15BrN2O | | MW: | 343.22 | | EINECS: | | | Product Categories: | Angiogenesis and Metastasis | | Mol File: | 288144-20-7.mol |  |
| | VEGFR2 Kinase Inhibitor II Chemical Properties |
| storage temp. | -20C | | solubility | DMF: 20 mg/ml; DMSO: 10 mg/ml | | form | Brown solid |
| | VEGFR2 Kinase Inhibitor II Usage And Synthesis |
| General Description | A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM). | | Biochem/physiol Actions | Cell permeable: yes |
| | VEGFR2 Kinase Inhibitor II Preparation Products And Raw materials |
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