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VDM Biochemicals
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Product Name:VEGFR2 Kinase Inhibitor II CAS:288144-20-7 Purity:>=95% by HPLC Package:80USD/1mg
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Sigma-Aldrich
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021-61415566 800-8193336 |
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Product Name:VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem
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BOC Sciences
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16314854226 |
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Product Name:VEGFR2 Kinase Inhibitor II CAS:288144-20-7 Purity:95% Package:1G;10G;100G Remarks:VEGFR2 kinase inhibitor II is a reversible and cell-permeable inhibitor of VEGFR2’s kinase activity with IC50 value of 70 nM. It also less potently inhibits the platelet-derived growth factor receptor
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
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Product Name:VEGFR2 Kinase Inhibitor II CAS:288144-20-7 Purity:>98% Package:1mg;10mg;50mg;100mg;
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| VEGFR2 Kinase Inhibitor II Basic information |
Product Name: | VEGFR2 Kinase Inhibitor II | Synonyms: | VEGFR2 Kinase Inhibitor II;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-;VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II | CAS: | 288144-20-7 | MF: | C17H15BrN2O | MW: | 343.22 | EINECS: | | Product Categories: | Angiogenesis and Metastasis | Mol File: | 288144-20-7.mol | ![VEGFR2 Kinase Inhibitor II Structure](CAS/20180808/GIF/288144-20-7.gif) |
| VEGFR2 Kinase Inhibitor II Chemical Properties |
storage temp. | -20C | solubility | DMF: 20 mg/ml; DMSO: 10 mg/ml | form | Brown solid |
| VEGFR2 Kinase Inhibitor II Usage And Synthesis |
General Description | A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM). | Biochem/physiol Actions | Cell permeable: yes |
| VEGFR2 Kinase Inhibitor II Preparation Products And Raw materials |
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