1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
| 中文名称 | 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
|---|---|
| 中文同义词 | 化合物 T14779;化合物BRD7389;1-(苯乙基氨基)-2H-萘并[1,2,3-DE]喹啉-2,7(3H)-二酮;BRD-7389,P90核糖体S6激酶RSK抑制剂 |
| 英文名称 | 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| 英文同义词 | BRD 7389;3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]-;1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione;1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione;Insulin Expression Inducer, BRD7389;BRD 7389 (BRD7389);Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem |
| CAS号 | 376382-11-5 |
| 分子式 | C24H18N2O2 |
| 分子量 | 366.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 376382-11-5.mol |
| 结构式 | ![1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione 结构式](CAS/GIF/376382-11-5.gif) |
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione 性质
| 沸点 | 655.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 11.31±0.40(Predicted) |
| 颜色 | 橙色 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
|
RSK1 1.5 μM (IC 50 ) |
RSK2 2.4 μM (IC 50 ) |
RSK3 1.2 μM (IC 50 ) |
CDK5/p35 6.5 μM (IC 50 ) |
DRAK1 2.8 μM (IC 50 ) |
FLT3 3.5 μM (IC 50 ) |
PIM1 3.7 μM (IC 50 ) |
PKG1α 6.5 μM (IC 50 ) |
SGK 13.8 μM (IC 50 ) |
BRD7389 (0.425-6.8 μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85 μM.
BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line.
BRD7389 also increases β-cell-specific gene expression in primary human islet cells.
BRD7389 (1 μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation.
RT-PCR
| Cell Line: | Mouse α-cell line |
| Concentration: | 0.425, 0.85, 1.7, 3.4, 6.8 μM |
| Incubation Time: | 3 days and 5 days |
| Result: | Up-regulated expression of Pdx1. |
Cell Proliferation Assay
| Cell Line: | SNU-407 colon cancer cell |
| Concentration: | 1 μM |
| Incubation Time: | Added 30 min prior to Carbachol treatment (48 h) |
| Result: | Almost completely blocked Carbachol (1 mM)-stimulated cell proliferation. |
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12185 | BRD7389 | 5 mg | 1000元 | |
| 2024/04/30 | HY-12185 | 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione BRD7389 | 376382-11-5 | 10mg | 1700元 |