RWJ 50271
| 中文名称 | RWJ 50271 |
|---|---|
| 中文同义词 | 化合物RWJ 50271;N-(3-羟丙基)-5-甲基-1-(4-(3-(三氟甲基)苯基)噻唑-2-基)-1H-吡唑-4-甲酰胺;RWJ 50271,LFA-1 / ICAM介导的细胞粘附抑制剂 |
| 英文名称 | RWJ 50271 |
| 英文同义词 | RWJ 50271;N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxamide;N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, N-(3-hydroxypropyl)-5-methyl-1-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-;N-(3-Hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carboxamide;inhibit,RWJ 50271,arthritis,RWJ-50271,organ,Inhibitor,transplantation,cell,Integrin,RWJ50271,rheumatoid,adhesion,molecules |
| CAS号 | 162112-37-0 |
| 分子式 | C18H17F3N4O2S |
| 分子量 | 410.41 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 162112-37-0.mol |
| 结构式 |  |
RWJ 50271 性质
| 密度 | 1.44±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | <41.04mg/ml，溶于 DMSO |
| 酸度系数(pKa) | 14.28±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.
RWJ 50271 inhibits both human and murine NK activity (IC
50
=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay.
RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations.
RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells.
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.
RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.
RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.
| Animal Model: | Mice, the delayed-type hypersensitivity [DTH] reaction model |
| Dosage: | 50 mg/kg |
| Administration: | Oral administration |
| Result: | Significantly reduced foot pad swelling (>50%) 48 h after the challenge. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110086 | RWJ 50271 | 1 mg | 900元 | |
| 2024/04/30 | HY-110086 | RWJ 50271 RWJ 50271 | 162112-37-0 | 5mg | 1800元 |