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CAY10499

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CAY10499 Suppliers list
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:CAY10499
CAS:359714-55-9
Purity:98% HPLC Package:10mg，500mg，1g，5g，10g
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:MAGL-IN-5
CAS:359714-55-9
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:MAGL-IN-5
CAS:359714-55-9
Purity:99% Package:$80.9/5mg;$130.9/10mg;$260.9/25mg;$410.9/50mg;$650.9/100mg;Bulk package Remarks:99%
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  Gold
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:CAY10499
CAS:359714-55-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:CAY10499
CAS:359714-55-9
Purity:98% Package:1g
CAY10499 Basic information
Product Name:CAY10499
Synonyms:CAY10499;QTENHWTVRQKWRI-UHFFFAOYSA-N;CAY10499 Exclusive;Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL;Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
CAS:359714-55-9
MF:C18H17N3O5
MW:355.34
EINECS:
Product Categories:
Mol File:359714-55-9.mol
CAY10499 Structure
CAY10499 Chemical Properties
density 1.31±0.1 g/cm3(Predicted)
solubility Soluble in DMSO
form crystalline solid
pka13.31±0.70(Predicted)
color Off-white to yellow
Safety Information
MSDS Information
CAY10499 Usage And Synthesis
DescriptionCAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 μM, respectively). In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.
DefinitionChEBI: CAY10499 is a carbamate ester.
references[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594.
CAY10499 Preparation Products And Raw materials
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