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BOC Sciences
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Product Name:CAY10590
CAS:1101136-50-8
Purity:98% Package:1G;10G;100G Remarks:Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary t
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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:CAY10590
CAS:1101136-50-8
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:CAY10590
CAS:1101136-50-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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TargetMol Chemicals Inc.
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4008200310 |
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Product Name:CAY10590
CAS:1101136-50-8
Package:50mg/RMB 19600;10mg/RMB 4950;5mg/RMB 2810
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| | CAY10590 Basic information |
| Product Name: | CAY10590 | | Synonyms: | CAY10590;4-[(1-Oxo-7-phenylheptyl)amino]-(4R)-octanoic acid;ANTPELWBOPVWPH-LJQANCHMSA-N;Octanoic acid, 4-[(1-oxo-7-phenylheptyl)amino]-, (4R)- | | CAS: | 1101136-50-8 | | MF: | C21H33NO3 | | MW: | 347.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1101136-50-8.mol |  |
| | CAY10590 Chemical Properties |
| Melting point | 73-75 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4)) | | Boiling point | 567.8±43.0 °C(Predicted) | | density | 1.028±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 4.60±0.10(Predicted) | | color | White to off-white |
| | CAY10590 Usage And Synthesis |
| Description | Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis.1 Three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2).2 Of these three enzymes, cPLA2 is the rate-limiting stimulus for release of arachidonic acid whereas sPLA2 amplifies the action of cPLA2 and regulates phagocytosis and foam cell formation.3 CAY10590, a simple amide based on (R)-γ-norleucine, is a potent and selective inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2.4 | | References | 1. Dennis, E.A. Phospholipases The Enzymes XVI,(1983).
2. Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2 J. Biol. Chem. 269,13057-13060(1994).
3. Balestrieri, B., and Arm, J.P. Group V sPLA2: Classical and novel functions Biochim. Biophys. Acta 1761,1280-1288(2006).
4. Antonopoulou, G., Barbayianni, E., Magrioti, V., et al. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes Bioorg. Med. Chem. 16,10257-10269(2008). |
| | CAY10590 Preparation Products And Raw materials |
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