| Company Name: |
Shanghai Champ Biopharmaceuticals Co., Ltd.
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| Tel: |
021-61537865 13585780846 |
| Email: |
sales@champchem.com |
| Products Intro: |
Product Name:rilmenidine D4
CAS:85047-14-9
Purity:0.98 Package:100mg/1g/1kg Remarks:isotope labeled compound
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| Company Name: |
Zhengzhou Acme Chemical Co., Ltd.
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| Tel: |
0371-037163312495,13303845143 13303845143 |
| Email: |
3001379618@qq.com |
| Products Intro: |
Product Name:Rilmenidine-d4
CAS:85047-14-9
Purity:98% Package:5g；25g；100g；500g
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Rilmenidine-d4
CAS:85047-14-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | Rilmenidine-d4 Basic information |
| Product Name: | Rilmenidine-d4 | | Synonyms: | Rilmenidine-d4;4,4,5,5-tetradeuterio-N-(dicyclopropylmethyl)-1,3-oxazol-2-amine;Rilmenidine D4Q: What is
Rilmenidine D4 Q: What is the CAS Number of
Rilmenidine D4 Q: What is the storage condition of
Rilmenidine D4 Q: What are the applications of
Rilmenidine D4 | | CAS: | 85047-14-9 | | MF: | C10H12D4N2O | | MW: | 184.271487112 | | EINECS: | 604-604-1 | | Product Categories: | isotope labeled compound | | Mol File: | 85047-14-9.mol |  |
| | Rilmenidine-d4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble,DMSO: Soluble,Methanol: Soluble | | form | A solid |
| | Rilmenidine-d4 Usage And Synthesis |
| Biological Activity | Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine by GC- or LC-MS. Rilmenidine is an antihypertensive agent.1 It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.2 Rilmenidine (1 μM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.3 Formulations containing rilmenidine have been used in the treatment of hypertension. | | References | 1.Gomez, R.E., Ernsbarger, P., Feinland, G., et al.Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 areaEur. J. Pharmacol.195(2)181-191(1991)
2.Burke, S.L., Evans, R.G., and Head, G.A.Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertensionJ. Hypertens.29(5)945-952(2011)
3.Williams, A., Sarkar, S., Cuddon, P., et al.Novel targets for Huntington's disease in an mTOR-independent autophagy pathwayNat. Chem. Biol.4(5)295-305(2008) |
| | Rilmenidine-d4 Preparation Products And Raw materials |
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