| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:DMAPT
CAS:870677-05-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Tel: |
029-61856359 19815193980 |
| Email: |
1018@dideu.com |
| Products Intro: |
Product Name:DMAPT
CAS:870677-05-7
Purity:98%
|
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| Product Name: | DMAPT | | Synonyms: | DMAPT;(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one;UJNSFDHVIBGEJZ-KVUCBBCISA-N;Dimethylamino Parthenolide;Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-;NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB | | CAS: | 870677-05-7 | | MF: | C17H27NO3 | | MW: | 293.4 | | EINECS: | | | Product Categories: | | | Mol File: | 870677-05-7.mol |  |
| | DMAPT Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO, Ethyl acetate, or Ethanol. | | form | solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month. |
| | DMAPT Usage And Synthesis |
| Description | DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2 | | Uses | DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents. | | References | 1) Shanmugam?et al. (2011),?A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer,?128?2481
2) Estrabrook?et al. (2011),?Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med.,?51?2249 |
| | DMAPT Preparation Products And Raw materials |
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