| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:SIRT2 Inhibitor, Inactive Control, AGK7
CAS:304896-21-7
Purity:>=97%
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:AGK7
CAS:304896-21-7
Purity:≥95% Remarks:AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with
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| | SIRT2 Inhibitor, Inactive Control, AGK7 Basic information |
| Product Name: | SIRT2 Inhibitor, Inactive Control, AGK7 | | Synonyms: | SIRT2 Inhibitor, Inactive Control, AGK7;AGK7;2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide;2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-;Parkinson's disease,sirtuin 2,morphology,SIRT2 Inhibitor,Inactive Control,AGK 7,Drosophila,inhibit,toxicity,Inhibitor,AGK7,alpha-synuclein,dopaminergic cell death,AGK-7,Sirtuin | | CAS: | 304896-21-7 | | MF: | C23H13Cl2N3O2 | | MW: | 434.27 | | EINECS: | | | Product Categories: | | | Mol File: | 304896-21-7.mol |  |
| | SIRT2 Inhibitor, Inactive Control, AGK7 Chemical Properties |
| storage temp. | +2C to +8C | | solubility | ≤0.5mg/ml in DMSO;0.2mg/ml in dimethyl formamide | | form | Yellow solid |
| | SIRT2 Inhibitor, Inactive Control, AGK7 Usage And Synthesis |
| Description | AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC50 values greater than 50 μM on SIRT1 and SIRT2 and greater than 5 μM on SIRT3. | | references | [1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science. 2007 jul 27;317(5837):516-9.
[2]. cole pa. chemical probes for histone-modifying enzymes. nat chem biol. 2008 oct;4(10):590-7. |
| | SIRT2 Inhibitor, Inactive Control, AGK7 Preparation Products And Raw materials |
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