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Product Name:Pimobendan (hydrochloride) CAS:77469-98-8 Purity:>98% Package:1265RMB/5mg
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| PiMobendan (hydrochloride) Basic information |
Product Name: | PiMobendan (hydrochloride) | Synonyms: | PiMobendan (hydrochloride);4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone monohydrochloride | CAS: | 77469-98-8 | MF: | C19H19ClN4O2 | MW: | 370.83276 | EINECS: | | Product Categories: | | Mol File: | 77469-98-8.mol | |
| PiMobendan (hydrochloride) Chemical Properties |
Melting point | 311°(dec) | storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | Powder |
Toxicity | LD50 orally in mice: ~600 mg/kg (Austel, 1982) |
| PiMobendan (hydrochloride) Usage And Synthesis |
Biological Activity | Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC50 of 320 nM. | in vitro | Pimobendan hydrochloride (UD-CG115 hydrochloride) exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC 50 of 0.32 uM compared to the inhibition of PDE I and PDE II ( IC 50 >30 μM). In human atrial cells, 100 μM Pimobendan (UD-CG115) significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC 50 ) of 1.13 μM. In rabbit atrial cells, Pimobendan (UD-CG115) increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells. | in vivo | Pimobendan (UD-CG115) shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan (UD-CG115) significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). It (UD-CG115) (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan (UD-CG115) suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. |
| PiMobendan (hydrochloride) Preparation Products And Raw materials |
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