192718-06-2
| 中文名称 | 192718-06-2 |
|---|---|
| 中文同义词 | 2-(4-氟苯基)萘并[2,3-D]恶唑-4,9-二酮;化合物C527 |
| 英文名称 | 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione |
| 英文同义词 | 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;C527;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;C527 >=98% (HPLC);Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit;2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione |
| CAS号 | 192718-06-2 |
| 分子式 | C17H8FNO3 |
| 分子量 | 293.25 |
| EINECS号 | |
| 相关类别 | 药品 |
| Mol文件 | 192718-06-2.mol |
| 结构式 |  |
192718-06-2 性质
| 沸点 | 488.6±47.0 °C(Predicted) |
|---|---|
| 密度 | 1.433±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 在DMSO中的溶解度为0.3mg/mL，澄清（加热） |
| 酸度系数(pKa) | -4.21±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深黄色 |
0.88 μM (USP1)
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-12988 | C527 | 1 mg | 240元 | |
| 2024/08/19 | HY-12988 | 192718-06-2 C527 | 192718-06-2 | 5mg | 600元 |