| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Aroplatin
CAS:114488-24-3
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
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Aroplatin manufacturers
- Aroplatin
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- $1520.00 / 25mg
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2024-10-24
- CAS:114488-24-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Aroplatin Basic information |
| | Aroplatin Chemical Properties |
| | Aroplatin Usage And Synthesis |
| Description | Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-strand DNA crosslinks and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACH?–platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile. |
| | Aroplatin Preparation Products And Raw materials |
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