| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Dynasore hydrate
CAS:1202867-00-2
Purity:Dynasore hydrate Package:25MG Remarks:D7693-25MG
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Dynasore hydrate
CAS:1202867-00-2
Purity:98% (HPLC) Package:25mg;5mg Remarks:NULL
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Product Name:Dynasore hydrate
CAS:1202867-00-2
|
|
| | Dynasore hydrate
Basic information |
| | Dynasore hydrate
Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | off-white |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 22-24/25-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| | Dynasore hydrate
Usage And Synthesis |
| Uses | Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
| | General Description | Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation. | | Biochem/physiol Actions | Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor. |
| | Dynasore hydrate
Preparation Products And Raw materials |
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