CHLAMYDOCIN
| 中文名称 | CHLAMYDOCIN |
|---|---|
| 中文同义词 | 环[2-甲基丙氨酰-L-苯丙氨酰-D-脯氨酰-(ALPHAS,2S)-ALPHA-氨基-H-氧代-2-环氧乙烷辛酰;衣菌素;化合物 CHLAMYDOCIN |
| 英文名称 | CHLAMYDOCIN |
| 英文同义词 | Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl];CHLAMYDOCIN;2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-];Antibiotic SL-3440;SL-3440;Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl] |
| CAS号 | 53342-16-8 |
| 分子式 | C28H38N4O6 |
| 分子量 | 526.63 |
| EINECS号 | |
| 相关类别 | Antibiotic |
| Mol文件 | 53342-16-8.mol |
| 结构式 |  |
CHLAMYDOCIN 性质
| 沸点 | 861.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：可溶；乙醇：可溶；甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.36±0.70(Predicted) |
Chlamydocin，一种真菌代谢产物，是一种高效的 HDAC 抑制剂，IC50 为 1.3 nM。Chlamydocin 具有很强的抗增殖和抗癌活性。Chlamydocin 通过激活 caspase-3 诱导细胞凋亡。
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HDAC 1.3 nM (IC 50 ) |
Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia . Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle.
安全信息
| 海关编码 | 29419000 |
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