| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Clostridium difficile Toxin A
Purity:>=95% (SDS-PAGE) Package:50UG Remarks:SML1154-50UG
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:lyophilized powder
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| Company Name: |
kemikalieimport
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| Tel: |
+ 45 - 2034 3359 |
| Email: |
Sales@kemikalieimport.dk |
| Products Intro: |
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | CLOSTRIDIUM DIFFICILE TOXIN A Basic information |
| | CLOSTRIDIUM DIFFICILE TOXIN A Chemical Properties |
| storage temp. | 2-8°C | | form | lyophilized powder |
| | CLOSTRIDIUM DIFFICILE TOXIN A Usage And Synthesis |
| General Description | Native toxin A purified from C. difficile strain VPI10463 (toxinotype 0) | | Biochem/physiol Actions | Clostridium difficile Toxin A and B, cation-dependent UDP-glucose glucosyltransferases, are cellular toxins that inactivate Rho (and Rho family small GTPases) through monoglucosylation of these family members. TcdA elicits effects primarily within the intestinal epithelium. Effects of this monoglucosylation include disregulation of the actin cytoskeleton, cell rounding, cytotoxicity, and altered cellular signaling. Rho proteins are monoglucosylated by Toxin A and B using UDP-glucose as a cosubstrate. Rho, Rac and Cdc42 are included in the Rho subfamilies targeted by both toxins. Low molecular mass GTP-binding proteins that are not modified by Toxin A and B include Ras, Rab, Arf, or Ran subfamilies as well as heterotrimeric G proteins. |
| | CLOSTRIDIUM DIFFICILE TOXIN A Preparation Products And Raw materials |
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