| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:clone 15A3, 1 mg/mL, purified immunoglobulin
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| Company Name: |
Alexis Corporation
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| Tel: |
+41 61 926 8989 |
| Email: |
alexis-ch@alexis-corp.ch |
| Products Intro: |
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| | ANTI-8-HYDROXYGUANOSINE Basic information |
| Product Name: | ANTI-8-HYDROXYGUANOSINE | | Synonyms: | ANTI-8-HYDROXYGUANOSINE;ANTI-8-HYDROXYGUANOSINE GOAT PAB;ANTI-8OHDG;ANTI-8-OHG GOAT PAB;ANTI-8-OXO-G GOAT PAB;Anti-8OHG;Anti-DNA/RNA Damage;Monoclonal Anti-DNA/RNA Damage antibody produced in mouse | | CAS: | | | MF: | C10H13N5O6 | | MW: | 299.24012 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | ANTI-8-HYDROXYGUANOSINE Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| | ANTI-8-HYDROXYGUANOSINE Usage And Synthesis |
| General Description | DNA/RNA damage, also known as 8-hydroxyguanine (8-OHG), is a product of oxidized DNA or RNA. | | Biochem/physiol Actions | 8-hydroxyguanine (8-OHG) helps in determining the reactive oxygen species (ROS)-induced modification of a purine residue in DNA. It is a sensitive marker of oxidative DNA damage. Overexpression of the gene has been observed in diabetic patients, especially those with advanced microvascular complications. Thus, 8-OHG functions as a novel biomarker for identifying oxidative DNA damage in diabetic patients. Plasma level of 8-OHG elevates with the age, with cigarette smoking and during tumorigenesis. 8-OHG levels in urine is considered as a biomarker of the total systemic oxidative stress in vivo. Overexpression of 8-OHG has been observed in various neurodegenerative diseases such as Parkinson′s disease (PD) and multiple system atrophy (MSA). |
| | ANTI-8-HYDROXYGUANOSINE Preparation Products And Raw materials |
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