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| | 3-methyl toxoflavin Basic information |
| Product Name: | 3-methyl toxoflavin | | Synonyms: | 3-methyl toxoflavin;Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl-;Inhibitor,3 Methyltoxoflavin,3-Methyltoxoflavin,3Methyltoxoflavin,inhibit;1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione;trimethyl-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | | CAS: | 32502-62-8 | | MF: | C8H9N5O2 | | MW: | 207.19 | | EINECS: | | | Product Categories: | | | Mol File: | 32502-62-8.mol |  |
| | 3-methyl toxoflavin Chemical Properties |
| Boiling point | 285.0±23.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 150 mg/mL (723.97 mM) | | form | Solid | | pka | -1.80±0.20(Predicted) | | color | Light yellow to yellow |
| | 3-methyl toxoflavin Usage And Synthesis |
| Definition | ChEBI: 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione is a pyrimidotriazine. | | Biological Activity | 3-Methyltoxoflavin is a potent inhibitor of protein disulfide isomerase (PDI) with IC50 of 170 nM. | | in vitro | 3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy . Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis. | | target | |
| | 3-methyl toxoflavin Preparation Products And Raw materials |
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