| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:SMER18
CAS:944153-47-3
Purity:>98% Package:2333RMB/2mg
|
| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:SMER18
CAS:944153-47-3
Purity:>98% Package:2333RMB/2mg
|
SMER18 manufacturers
- SMER18
-
- $135.00 / 1mg
-
2024-11-19
- CAS:944153-47-3
- Min. Order:
- Purity: 97.27%
- Supply Ability: 10g
|
| Product Name: | SMER18 | | Synonyms: | SMER18;CS-2054;Reaxys ID: 18302282;2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-;SMER18,SMER-18;(Z)-1-(4-Chlorophenyl)-3-((3-hydroxyphenyl)amino)but-2-en-1-one | | CAS: | 944153-47-3 | | MF: | C16H14ClNO2 | | MW: | 287.74 | | EINECS: | | | Product Categories: | | | Mol File: | 944153-47-3.mol |  |
| | SMER18 Chemical Properties |
| Boiling point | 458.7±45.0 °C(Predicted) | | density | 1.298±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.83±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | SMER18 Usage And Synthesis |
| Uses | SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.
Target: mTOR
SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. | | References | [1] Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338. DOI:10.1038/nchembio883 |
| | SMER18 Preparation Products And Raw materials |
|