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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Nemiralisib；GSK2269557 (free base)
CAS:1254036-71-9
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name: 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS:1254036-71-9
Purity:58799% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
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Products Intro: Product Name:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS:1254036-71-9
Remarks:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Nemiralisib (GSK2269557)
CAS:1254036-71-9
Purity:98% Package:25mg Remarks:V2539
Company Name: Hebei Miaoyin Technology Co.,Ltd
Tel: +86-17367732028 +86-17367732028
Email: kathy@hbyinsheng.com
Products Intro: Product Name:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS:1254036-71-9
Purity:99.99% Package:1g;1USD
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Basic information
Product Name:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
Synonyms:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole;GSK2269557 (free base);1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-;PI3Kδ inhibitor GS2269557;CS-2340;gsk2269557(Nemiralisib);Nemiralisib(GSK2269557);Nemiralisib (GSK2269557 free base)
CAS:1254036-71-9
MF:C26H28N6O
MW:440.54
EINECS:
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Mol File:1254036-71-9.mol
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Structure
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Chemical Properties
Boiling point 706.2±70.0 °C(Predicted)
density 1.281±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 33.33 mg/mL (75.66 mM)
form Solid
pka12.90±0.40(Predicted)
color White to yellow
Safety Information
MSDS Information
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Usage And Synthesis
Biological ActivityNemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9).
in vivoNemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and Tpe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed.
target
TargetValue
PI3Kδ
(Cell-free assay)		 9.9(pKi)
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Preparation Products And Raw materials
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