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Product Name: | BCI | Synonyms: | BCI;BCI - NSC 150117;(E)-BCI;1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-, (2E)-;inhibit,Phosphatase,BCI,Inhibitor | CAS: | 1245792-51-1 | MF: | C22H23NO | MW: | 317.42 | EINECS: | | Product Categories: | | Mol File: | 1245792-51-1.mol | ![BCI Structure](CAS/20200515/GIF/1245792-51-1.gif) |
storage temp. | Store at -20°C | solubility | DMSO:125.0(Max Conc. mg/mL);393.79(Max Conc. mM) | form | Solid | color | Off-white to yellow |
Description | BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively. | Definition | ChEBI: (2E)-2-benzylidene-3-(cyclohexylamino)indan-1-one is a 2-benzylidene-3-(cyclohexylamino)indan-1-one in which the double bond has E configuration. An inhibitor of the dual specificity phosphatase 6 (Dusp6). It has a role as an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and an apoptosis inducer. |
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