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| | HIF-2a Translation Inhibitor 76 Basic information |
| Product Name: | HIF-2a Translation Inhibitor 76 | | Synonyms: | HIF-2a Translation Inhibitor 76;HIF-2a translation inhibitor;HIF-2α-IN-4;HIF 2α IN 4,iron-responsive,oxygen sensing,HIF-2α,HIF/HIF Prolyl-Hydroxylase,translation,HIF-PH,hypoxia,HIF2αIN4,inhibit,HIFs,Hypoxia-inducible factors,Inhibitor;2-Thiophenecarboxylic acid, 3-[[cyano(methylsulfonyl)methylene]hydrazinyl]-, methyl ester;HIF-2α Translation Inhibitor | | CAS: | 882268-69-1 | | MF: | C9H9N3O4S2 | | MW: | 287.32 | | EINECS: | | | Product Categories: | | | Mol File: | 882268-69-1.mol |  |
| | HIF-2a Translation Inhibitor 76 Chemical Properties |
| Boiling point | 454.3±55.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 5.38±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | HIF-2a Translation Inhibitor 76 Usage And Synthesis |
| Biological Activity | HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].
HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1]. | | References | [1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848. |
| | HIF-2a Translation Inhibitor 76 Preparation Products And Raw materials |
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