| Company Name: |
Shanghai Rechem science Co., Ltd.
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| Tel: |
21-31433387 15618786686 |
| Email: |
sales@rechemscience.com |
| Products Intro: |
CAS:1680196-54-6
Purity:98% Package:1g;10g
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| Product Name: | FzM1 | | Synonyms: | FzM1;FzM1
(Fzd4 modulator FzM1;FzM1 >=98% (HPLC);Urea, N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-;N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea | | CAS: | 1680196-54-6 | | MF: | C21H16N2O2S | | MW: | 360.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1680196-54-6.mol |  |
| Boiling point | 518.3±50.0 °C(Predicted) | | density | 1.401±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 12 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | 9.42±0.10(Predicted) | | color | White to light brown |
| Description | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 μM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells. |
| | FzM1 Preparation Products And Raw materials |
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