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Product Name:GQ-16
CAS:870554-67-9
Purity:98% Package:1G;10G;100G Remarks:GQ-16 is an effective and partial agonist for peroxisome proliferator-activated receptor γ (PPARγ) (Ki = 160 nM). It does not activate PPARα, PPARβ/δ, or RXRα.
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GQ-16 manufacturers
- GQ-16
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- $33.00 / 10mg
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2024-10-30
- CAS:870554-67-9
- Min. Order:
- Purity: 99.12%
- Supply Ability: 10g
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| Product Name: | GQ-16 | | Synonyms: | GQ-16;5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione;(5Z)-5-[(5-bromo-2-methoxyphenyl)methylidene]-3-[(4-methylphenyl)methyl]-1,3-thiazolidine-2,4-dione;GQ-16 Exclusive;PPAR,Inhibitor,reduced adipogenic actions,PPARγ,GQ-16,insulin sensitization,inhibit,Peroxisome proliferator-activated receptors,insulin Resistance,GQ16,GQ 16;2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)- | | CAS: | 870554-67-9 | | MF: | C19H16BrNO3S | | MW: | 418.3 | | EINECS: | | | Product Categories: | | | Mol File: | 870554-67-9.mol |  |
| | GQ-16 Chemical Properties |
| Melting point | 147 °C | | Boiling point | 549.8±60.0 °C(Predicted) | | density | 1.522±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤0.33mg/ml in DMSO;5mg/ml in dimethyl formamide | | form | crystalline solid | | pka | -2.57±0.20(Predicted) | | color | Off-white to light yellow |
| | GQ-16 Usage And Synthesis |
| Description | Full activation of peroxisome proliferator-activated receptor γ (PPARγ), e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema. GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone. Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling. However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα. | | in vitro | gq-16 was an effective inhibitor of cdk5-mediated phosphorylation of pparγ, exhibiting a ki value of 160 nm. gq-16 was specific for pparγ and possessed no detectable activity when tested for the ability to activate other ppar subtypes (pparα or pparβ/δ) or rxrα. in both nih-3t3 and c3h10t1/2 cell models with established pparγ-dependent adipogenesis, gq-16 displayed reduced the potential of adipogenic [1]. | | in vivo | in the mouse model of diet-induced obesity and insulin resistance, administration of gq-16 (20 mg/kg/day) by oral gavage daily blocked hfd-dependent effects on intracellular inflammatory pathways and improved insulin sensitivity. gq-16 did not elicit increased weight gain [1]. | | references | [1] amato a a, rajagopalan s, lin j z, et al. gq-16, a novel peroxisome proliferator-activated receptor γ (pparγ) ligand, promotes insulin sensitization without weight gain[j]. journal of biological chemistry, 2012, 287(33): 28169-28179. |
| | GQ-16 Preparation Products And Raw materials |
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