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| 5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid Basic information |
| 5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid Chemical Properties |
Boiling point | 875.4±65.0 °C(Predicted) | density | 1.43±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 83.3 mg/mL (147.27 mM) | pka | 2.11±0.10(Predicted) | form | Solid | color | Light yellow to yellow |
| 5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid Usage And Synthesis |
Uses | MK-4074, strongly inhibits acetyl-CoA carboxylase, both ACC1 and ACC2 with IC50 values of approximately 3 nM. s highly liver specific because it is a substrate of organic anion transport protein (OATP) transporters that are present only in hepatocytes. |
| 5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinicacid Preparation Products And Raw materials |
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