| Company Name: |
Alpha Biopharmaceuticals Co., Ltd
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| Tel: |
0411-39042497 |
| Email: |
sales@alphabiopharm.com |
| Products Intro: |
Product Name:Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
Purity:98% HPLC Package:1g,5g,25g,100g,500g,1kg Remarks:F0623
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| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
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| Tel: |
025-85563444 18351873721 |
| Email: |
purchase@synzest.com |
| Products Intro: |
Product Name:Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
CAS:2408741-87-5
Purity:95%HPLC Package:50mg;100mg;250mg;1g
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| | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 Basic information |
| Product Name: | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 | | Synonyms: | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24;MAL-dPEG??-Glu(TFP ester)-NH-m-dPEG???;9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78-Tetracosaoxa-6-azanonaheptacontanoic acid, 4-[[19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,17-dioxo-4,7,10,13-tetraoxa-16-azanonadec-1-yl]amino]-5-oxo-, 2,3,5,6-tetrafluorophenyl ester, (4S)- | | CAS: | 2408741-87-5 | | MF: | C78H134F4N4O35 | | MW: | 1763.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2408741-87-5.mol |  |
| | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 Chemical Properties |
| Boiling point | 1305.2±65.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | pka | 13.98±0.46(Predicted) |
| | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 Usage And Synthesis |
| Biological Activity | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 Preparation Products And Raw materials |
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