CRT0066101

CRT0066101 Suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:CRT0066101
CAS:1883545-60-5
Purity:98% Package:1g;1.3USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:CRT0066101
CAS:1883545-60-5
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:CRT0066101
CAS:1883545-60-5
Purity:99% Package:5KG;1KG Remarks:CRT0066101
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:CRT 0066101
CAS:1883545-60-5
Purity:98% Package:5mg Remarks:V11937
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:CRT0066101 dihydrochloride
CAS:1883545-60-5
Purity:99.85% Package:1mg;31USD|5mg;72USD|10mg;122USD

CRT0066101 manufacturers

CRT0066101 Basic information
Product Name:CRT0066101
Synonyms:CRT0066101 2HCL;CRT0066101 dihydrochloride;2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride;CRT0066101 (CRT-0066101;CS-2578;CRT0066101 hcl;Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit
CAS:1883545-60-5
MF:C18H23ClN6O
MW:374.87
EINECS:
Product Categories:
Mol File:1883545-60-5.mol
CRT0066101 Structure
CRT0066101 Chemical Properties
storage temp. Store at -20°C
solubility insoluble in H2O; ≥15.65 mg/mL in DMSO; ≥4.49 mg/mL in EtOH with ultrasonic
form solid
color Off-white to light yellow
Safety Information
MSDS Information
CRT0066101 Usage And Synthesis
Biological Activitycrt 0066101 is a specific inhibitor of all pkd isoforms. increasingly studies reveals that pkd family members play an important role in regulating several cellular processes and activities, including chromatin organization, golgi function, gene expression, cell survival, adhesion, motility, differentiation, dna synthesis and proliferation. by suppressing pkd, crt 0066101 is supposed to ameliorate symptoms of pancreatic cancer. [1]
in vitroin panc-1 cell line based assays, crt0066101 was reported to reduce bromodeoxyuridine incorporation; increase cell apoptosis; suppress neurotensin-induced pkd1/2 activation; block neurotensin-induced hsp27 phosphorylation; interrupt pkd1-mediated nf-κb activation as well as down-regulate expression of nf-κb-dependent proliferative and pro-survival proteins. [1]
in vivoin panc-1 subcutaneous xenograft model, orally administration of crt0066101 at the dosage of 80 mg/kg/d for 24 days significantly suppressed pancreatic cancer growth. moreover, when crt0066101 reached its peak concentration (12 μmol/l) in tumor model, the expression of activated pkd1/2 in the treated tumor explants was substantially decreased. it was concluded that crt0066101 given orally at 80 mg/kg/d for 21 days in panc-1 orthotropic model suppressed tumor growth potently in vivo. [1]
target< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PKD2
(Cell-free assay)
TargetValue
PKD1
(Cell-free assay)
1 nM
PKD3
(Cell-free assay)
2 nM
2.5 nM
IC 50a potent protein kinase d (pkd) antagonist with the ic50 of 1, 2.5 and 2 nm for pkd1, pkd2, pkd3 respectively.
storageStore at -20°C
references[1]harikumar kb, kunnumakkara1 ab, ochi n, tong z, deorukhkar a, sung b, kelland l, jamieson s, sutherland r, raynham t, charles m, bagherzadeh a, foxton c, boakes a, farooq m, maru d, diagaradjane p, matsuo y, smith j, gelovani j, krishnan s, aggarwal bb, rozengurt e, ireson cr, and guha s. a novel small-molecule inhibitor of protein kinase d blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther. 2010 may. 9(5): 113646.
CRT0066101 Preparation Products And Raw materials
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