ST-193 (hydrochloride)

ST-193 (hydrochloride)

中文名称ST-193 (hydrochloride)
中文同义词化合物 ST-193 HYDROCHLORIDE
英文名称ST-193 (hydrochloride)
英文同义词ST-193 (hydrochloride)
CAS号2320274-72-2
分子式C24H26ClN3O
分子量407.94
EINECS号
相关类别
Mol文件2320274-72-2.mol
结构式ST-193 (hydrochloride) 结构式

ST-193 (hydrochloride) 性质

形态固体
颜色白色至米白色

ST-193 (hydrochloride) 用途与合成方法

ST-193 hydrochloride是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。

IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)

ST-193 inhibits LASV pseudotypes with an IC 50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC 50 s for Junín, Machupo, Guanarito, and Sabiá are in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM.

ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/04/30HY-101441AST-193 hydrochloride1 mg1590元
2024/04/30HY-101441AST-193 (hydrochloride)
ST-193 hydrochloride
2320274-72-210mM * 1mLin DMSO3141元

ST-193 (hydrochloride) 上下游产品信息

"ST-193 (hydrochloride)"相关产品信息
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