167626-17-7
| 中文名称 | 167626-17-7 |
|---|---|
| 中文同义词 | 化合物 T13804;化合物 OPC-28326 |
| 英文名称 | OPC-28326 |
| 英文同义词 | OPC-28326;OPC28326,OPC 28326;Propanamide, N-[2,6-dimethyl-4-[[4-[methyl(2-phenylethyl)amino]-1-piperidinyl]carbonyl]phenyl]- |
| CAS号 | 167626-17-7 |
| 分子式 | C26H35N3O2 |
| 分子量 | 421.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 167626-17-7.mol |
| 结构式 |  |
167626-17-7 性质
| 沸点 | 624.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.13±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.79±0.70(Predicted) |
Ki: 2040 nM (α2A adrenoceptor), 285 nM (α2B adrenoceptor), 55 nM (α2C adrenoceptor)
OPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt. OPC-28326 (1-100 μM) and yohimbine (10-1000 nM) causes a rightward shift in the concentration-response curve of clonidine.
OPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS−/− mice. OPC-28326 (3-30 mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats.