Company Name: |
DC Chemicals
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Tel: |
021-58447131 13564518121 |
Email: |
sales@dcchemicals.com |
Products Intro: |
Product Name:ABT-719 HCl CAS:162763-53-3 Purity:98% HPLC Package:100mg,250mg,1g
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Company Name: |
Absin Bioscience Inc.
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Tel: |
021-38015121 15000105423 |
Email: |
chenjw@absin.cn |
Products Intro: |
Product Name:ABT-719 HCl CAS:162763-53-3 Purity:>98% Package:100mg;50mg
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:ABT-719 HCl;ABT719 HCl,ABT 719 HCl CAS:162763-53-3 Purity:98% Package:5 mg
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| 4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) Basic information |
| 4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) Chemical Properties |
| 4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) Usage And Synthesis |
Description | ABT-719 is a 2-pyridone antimicrobial with activity against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. Therapeutic ED50s for ABT-719 against these infections were equal to or up to ten-fold lower than those for ciprofloxacin, used as a reference because of similarity in mode of action. Against E. faecalis, the therapeutic ED50s for ABT-719 were 4.5-13.6 mg/kg.day for sc administration and 6.8-8.9 mg/kg.day for oral administration. ABT-719 was more potent than ciprofloxacin and vancomycin against the E. faecalis strains, which showed ciprofloxacin and vancomycin resistance covering a range of MICs. |
| 4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) Preparation Products And Raw materials |
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