- SMI-16a
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- $1.00 / 1g
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2019-12-24
- CAS:587852-28-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | SMI-16a Basic information |
| Product Name: | SMI-16a | | Synonyms: | SMI-16a;PIM1/2 Kinase Inhibitor VI;SMI-16a(PIM1/2 Kinase Inhibitor VI);SMI-16A;SMI 16A;SMI16A;2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-;SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases;5-(4-propoxybenzylidene)thiazolidine-2,4-dione | | CAS: | 587852-28-6 | | MF: | C13H13NO3S | | MW: | 263.31 | | EINECS: | | | Product Categories: | | | Mol File: | 587852-28-6.mol |  |
| | SMI-16a Chemical Properties |
| Melting point | 186.3-188.4 °C | | density | 1.303±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM) | | form | A solid | | pka | 7.27±0.20(Predicted) | | color | Light yellow to yellow |
| | SMI-16a Usage And Synthesis |
| Description | SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells. |
| | SMI-16a Preparation Products And Raw materials |
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