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FM-381

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:FM-381
CAS:2226521-65-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:FM-381
CAS:2226521-65-7
Purity:99.33% Package:1mg;48USD|5mg;113USD|10mg;163USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:(E)-2-CYANO-3-(5-(1-CYCLOHEXYL-1,6-DIHYDROIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-2-YL)FURAN-2-YL)-N,N-DIMETHYLACRYLAMIDE
CAS:2226521-65-7
Purity:Min98% HPLC/GC Package:1g;1USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:FM-381
CAS:2226521-65-7
Purity:99% Package:5KG;1KG Remarks:FM-381
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:FM-381
CAS:2226521-65-7
Purity:98% Package:5mg Remarks:V3114

FM-381 manufacturers

  • FM-381
  • FM-381 pictures
  • $48.00 / 1mg
  • 2024-11-19
  • CAS:2226521-65-7
  • Min. Order:
  • Purity: 99.33%
  • Supply Ability: 10g
FM-381 Basic information
Product Name:FM-381
Synonyms:FM-381;(E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide;FM-381; FM 381; FM381;CS-2854;2-Propenamide, 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-;2-Propenamide,2-cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-,(2E)-;2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide;inhibit,JAK,FM-381,Inhibitor,Janus kinase,FM 381
CAS:2226521-65-7
MF:C24H24N6O2
MW:428.49
EINECS:
Product Categories:
Mol File:2226521-65-7.mol
FM-381 Structure
FM-381 Chemical Properties
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear (warmed)
form powder
color white to beige
Safety Information
MSDS Information
FM-381 Usage And Synthesis
Biological ActivityFM-381 is a highly potent and JAK3-selective janus kinase (JAK) inhibitor (IC50 = 127 pM/JAK3, 52 nM/JAK1, 346 nM/JAK2, 459 nM/TYK2 by radiometric assay; [ATP] = 10 μM) th at targets JAK3 gatekeeper (GK) Cys909 for a reversible covalent interaction, exhibiting much reduced or little potency against a panel of 409 other kinases. FM-381 is >3-fold more potent than the JAK1/3 inhibitor Tofacitinib (IC50 = 292 pM/JAK3, 496 pM/JAK1, 2.2 nM/JAK2, 8.9 nM/TYK2 by radiometric assay; [ATP] = 10 μM) in blocking JAK1/JAK3-mediated STAT5 phosphorylation in human CD4+ T-cells upon IL-2 stimulation (ECmax ∼100 nM with FM-381), while being ineffective (up to 1 μM) against JAK3-independent STAT1/3 phosphorylation following IL-6 or TNFα stimulation. For characterization details of FM-381, please visit the FM-381 probe summary on the Structural Genomics Consortium (SGC) website.

FM-479 is the negative control for the active probe, FM-381. FM-479 is available from Sigma. To learn more about and purchase FM-479, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc
FM-381 Preparation Products And Raw materials
Tag:FM-381(2226521-65-7) Related Product Information
FM479 N-(3-TRIETHYLAMMONIUMPROPYL)-4-(4-(DIBUTYLAMINO)STYRYL)PYRIDINIUM DIBROMIDE ESTETROL Ethylamine (-)-Varitriol