1945950-21-9
| 中文名称 | 1945950-21-9 |
|---|---|
| 中文同义词 | 1-[(1,3-二甲基-1H-吡唑-5-基)甲基]-1,2,3,4-四氢-N-(1-甲基环丙基)-3-[(2-甲基-5-噻唑基]甲基]-2,4-二氧代-6-喹唑啉磺酰胺;化合物 T5700;PDD 00017273,PARG抑制剂 |
| 英文名称 | PDD 00017273 |
| 英文同义词 | PDD 00017273;1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide;6-Quinazolinesulfonamide, 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-;PDD00017273 >=98% (HPLC);PDD17273 |
| CAS号 | 1945950-21-9 |
| 分子式 | C23H26N6O4S2 |
| 分子量 | 514.62 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1945950-21-9.mol |
| 结构式 |  |
1945950-21-9 性质
| 沸点 | 733.9±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：10mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.67±0.20(Predicted) |
| Target | Value |
|
PARG
(Cell-free assay) | 26 nM |
PDD 00017273 is a potent inhibitor of PARG, with an IC 50 of 26 nM, and a K D of 1.45 nM. PDD 00017273 (10 μM) does not inhibit five common Cytochrome P450 enzymes. PDD 00017273 (30 μM) modestly increasess phosphorylated H2AX (γH2AX) intensity, PDD 00017273 also decreases in NAD/H through PARG inhibition after DNA damage. PDD 00017273 suppresses the ZR-75-1 cells carring BRCA1 and BRCA2 wild type, and exhibits less potent activities against MDA-MB-436 cells carry the 5396 + 1G>A mutation in BRCA1. PDD 00017273 (0.3 μM) inhibits degradation of PAR polymers in MCF7 cells. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108360 | 1945950-21-9 PDD 00017273 | 1945950-21-9 | 5mg | 1100元 |
| 2024/04/30 | HY-108360 | 1945950-21-9 PDD 00017273 | 1945950-21-9 | 10mM * 1mLin DMSO | 1245元 |