| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Z-VDVAD-FMK;Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoroMethylketone
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
GL Biochem (Shanghai) Ltd
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| Tel: |
21-61263452 13641803416 |
| Email: |
ymbetter@glbiochem.com |
| Products Intro: |
Product Name:Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone
Purity:95% HPLC,98% HPLC Package:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
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| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:Z-VDVAD-FMK
Purity:99%HPLC Package:370USD/5mg
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| | Z-VDVAD-FMK Basic information |
| Product Name: | Z-VDVAD-FMK | | Synonyms: | BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;CASPASE-2 INHIBITOR I;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-VDVAD-FLUOROMETHYLKETONE;Z-VDVAD-FMK | | CAS: | 210344-92-6 | | MF: | C32H46FN5O11 | | MW: | 695.73 | | EINECS: | | | Product Categories: | Caspases/Apoptosis;Caspase/Related Products | | Mol File: | Mol File |  |
| | Z-VDVAD-FMK Chemical Properties |
| storage temp. | −20°C | | solubility | DMSO/DMF: 20 mM | | form | powder | | color | white |
| | Z-VDVAD-FMK Usage And Synthesis |
| Biological Activity | Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. | | Biochem/physiol Actions | A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition. | | references | 1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223. |
| | Z-VDVAD-FMK Preparation Products And Raw materials |
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