OXYTHIAMINE HYDROCHLORIDE
| 中文名称 | OXYTHIAMINE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T12354;硫胺素(维生素B1)杂质19 |
| 英文名称 | OXYTHIAMINE HYDROCHLORIDE |
| 英文同义词 | Thiazolium,3-[(3,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-;Oxythiamine·HCl≥ 99% (assay);oxythiamine(1+);thiazolium,5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-m;5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE;5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE;5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-methyl-thi;azolium |
| CAS号 | 136-16-3 |
| 分子式 | C12H17Cl2N3O2S |
| 分子量 | 338.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 136-16-3.mol |
| 结构式 |  |
OXYTHIAMINE HYDROCHLORIDE 性质
| 密度 | 1.2416 (rough estimate) |
|---|---|
| 折射率 | 1.6740 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | 二甲基亚砜：51.67 mg/ml（194.00 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Oxythiamine 是一种抗代谢物和维生素B1 (vitamin B1)拮抗剂，也是众所周知的硫铵 (thiamine) 拮抗剂和转酮醇酶 (transketolase) 抑制剂。
Vitamin B1, Thiamine, Transketolase.
Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. Oxythiamine alters protein expression in a dose dependent manner. The level of alpha-enolase is increased by Oxythiamine treatment, while expression of 14-3-3 protein beta/alpha is suppressed by Oxythiamine at a stratified dose. Oxythiamine causes dynamic changes of total protein expression in time dependent fashion. Oxythiamine suppresses expression of cellular phosphor proteins significantly.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | XJ7034100 |
| 毒性 | LD50 scu-mus: 1430 mg/kg PCJOAU16,848,82 |
| 提供商 | 语言 |
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英文
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