6,2'-二羟基黄酮
中文名称 | 6,2'-二羟基黄酮 |
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中文同义词 | 6,2'-二羟基黄酮;2',6-二羟基黄酮,97%;2',6-二羟基黄酮;6,2'-二羟基黄酮 |
英文名称 | 2',6-DIHYDROXYFLAVONE |
英文同义词 | 6-hydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one, DHF;2',6-DIHYDROXYFLAVONE;6,2'-DIHYDROXYFLAVONE;4H-1-Benzopyran-4-one, 6-hydroxy-2-(2-hydroxyphenyl)-;6-hydroxy-2-(2-hydroxyphenyl)chromen-4-one;6,2'Dihydroxyflavone,Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,6,2'-Dihydroxyflavone,GABA Receptor,Inhibitor,inhibit,6,2' Dihydroxyflavone;6,2'-Dihydroxyflavone;2',6-DIHYDROXYFLAVONE |
CAS号 | 92439-20-8 |
分子式 | C15H10O4 |
分子量 | 254.24 |
EINECS号 | |
相关类别 | Di-substituted Flavones |
Mol文件 | 92439-20-8.mol |
结构式 | ![]() |
6,2'-二羟基黄酮 性质
储存条件 | Room temp |
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溶解度 | 二甲基亚砜:155 mg/mL(609.66 mM) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
GABA A receptor
6,2'-Dihydroxyflavone is a novel antagonist of GABA A receptor. 6,2'-Dihydroxyflavone inhibits [ 3 H]-flunitrazepam binding to the rat cerebral cortex membranes with a K i of 37.2±4.5 nM. The current elicited with the EC 50 concentration of GABA is decreased to 73.6±1.9% of control by co-application of 5 μM 6,2'-Dihydroxyflavone (n=5), compare to a decrease to 65.9±3.0% by 1 μM FG-7142 (n=5). The EC 50 for GABA dose response increases from 47.6 to 59.7 μM upon co-application of 5 μM 6,2'-Dihydroxyflavone, and the maximal GABA-current is decreased.
6,2'-Dihydroxyflavone-treated mice exhibit significant differences from control mice with respect to the percentage of open arms entries [F (4,73) =8.01, P<0.0001] and the percentage of time spent in open arms [F (4,73) =5.19, P<0.002], but not the number of entries to closed arms [F (4,73) = 0.79,P=0.54]. The post-hoc NewmaneKeuls’ tests confirm that 6,2'-Dihydroxyflavone significantly decreases the percentage of open arm entries and time spent in open arms at the doses of 8 and 16 mg/kg. 6,2'-Dihydroxyflavone treatment similarly increases step-through latency [F (4,75) =4.71, P<0.002], suggesting enhanced cognitive performance.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-N6628 | 6,2'-二羟基黄酮 6,2'-Dihydroxyflavone | 92439-20-8 | 10mM * 1mLin DMSO | 660元 |
2024/04/30 | HY-N6628 | 6,2'-Dihydroxyflavone | 100 mg | 900元 |