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| | GGTI-298 Basic information |
| Product Name: | GGTI-298 | | Synonyms: | GGTI-298;N-[[4-(2-(R)-AMINO-3-MERCAPTOPROPYL)AMINO]-2-NAPHTHYLBENZOYL]LEUCINE METHYL ESTER TRIFLUOROACETATE SALT;N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-NAPHTHYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;GGTI-298 trifluoroacetate salt;N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt;N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt;GGTI298 (CF3CO2H)salt;CS-2228 | | CAS: | 180977-44-0 | | MF: | C27H33N3O3S | | MW: | 479.63 | | EINECS: | 604-604-1 | | Product Categories: | A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297. | | Mol File: | Mol File |  |
| | GGTI-298 Chemical Properties |
| Melting point | 99.5-100 °C | | Boiling point | 673.7±55.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: 22 mg/mL | | form | solid | | pka | 9.83±0.10(Predicted) | | color | off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | GGTI-298 Usage And Synthesis |
| Uses | GGTI 298 is a CAAX peptidomimetic that selectively inhibits geranylgeranyltransferase I (GGTase I). It has been shown to arrest human tumor cells and induce apoptosis. | | Definition | ChEBI: (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)phenyl]-oxomethyl]amino]-4-methylpentanoic acid methyl ester is a leucine derivative. | | in vivo | The vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298, or H1152 when injected together with cholera toxin into the loop[1]. |
| | GGTI-298 Preparation Products And Raw materials |
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