Related articles - Synthesis of Enarodustat(JTZ-951)
- Enarodustat is synthesised using Dichloropyridine as a raw material through the reactions of lipo-conversion, substitution, re....
- Dec 22，2023
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| | JTZ-951 Basic information |
| Product Name: | JTZ-951 | | Synonyms: | JTZ-951;Enarodustat;Glycine, N-[[7-hydroxy-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl]-;(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine;JTZ-951(Enarodustat);enarodustat(JTZ-951);HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit,JTZ951,HIF-PH,Hypoxia-inducible factors,JTZ 951,Enarodustat,Inhibitor;2-(7-Hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamido)acetic acid | | CAS: | 1262132-81-9 | | MF: | C17H16N4O4 | | MW: | 340.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1262132-81-9.mol |  |
| | JTZ-951 Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:60.44(Max Conc. mg/mL);177.59(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);88.15(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);73.46(Max Conc. mM) | | form | A solid | | pka | 0.58±0.53(Predicted) | | color | White to off-white |
| | JTZ-951 Usage And Synthesis |
| Uses | Enarodustat is in the process of being approved for use in treating anemia associated with chronic kidney disease. |
| | JTZ-951 Preparation Products And Raw materials |
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