Pepstatin Trifluoroacetate
| 中文名称 | Pepstatin Trifluoroacetate |
|---|---|
| 中文同义词 | 抑肽素三氟醋酸盐 |
| 英文名称 | Pepstatin Trifluoroacetate |
| 英文同义词 | Pepstatin Trifluoroacetate |
| CAS号 | |
| 分子式 | C??H??F?N?O?? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
Pepstatin Trifluoroacetate 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease)
Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) is a specific acid protease inhibitor produced by actinomycetes, with IC 50 s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin (Pepstatin A) inhibits the recombinant HIV protease with an IC 50 of 250 μM. Pepstatin shows no effect on cellular protein synthesis and probably does not exert severe cell toxicity.
Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) has a very low toxicity, with LD 50 s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route. Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats.