| Company Name: |
Artis Biotech Co. Ltd.
|
| Tel: |
0575-18780151478 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Maprotiline D3 HCl
CAS:1329496-63-0
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
|
| Company Name: |
Chengdu Novel Biomedical Co., Ltd.
|
| Tel: |
028-85255396 18302801538 |
| Email: |
cdnovell@163.com |
| Products Intro: |
Product Name:Maprotiline D3 HCl
CAS:1329496-63-0
Purity:98% HPLC Package:100mg；200mg
|
| Company Name: |
Manhag Testing Technology Co., Ltd
|
| Tel: |
020-020-3846236 17688849268 |
| Email: |
2443244976@qq.com |
| Products Intro: |
Product Name:Maprotiline-[d3] hydrochloride
CAS:1329496-63-0
Purity:98.8 % Package:1mg
|
| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Maprotiline-d3 hydrochloride
CAS:1329496-63-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
|
| | [2H3]-Maprotiline hydrochloride Basic information |
| | [2H3]-Maprotiline hydrochloride Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble,Methanol: soluble | | form | A solid | | color | White to off-white |
| | [2H3]-Maprotiline hydrochloride Usage And Synthesis |
| Biological Activity | Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant.1,2 It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively).2 Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively).3 In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues.4 It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety. | | References | 1.Spencer, P.S.Review of the pharmacology of existing antidepressantsBr. J. Clin. Pharmacol.4(Suppl 2)57S-68S(1977)
2.Tatsumi, M., Groshan, K., Blakely, R.D., et al.Pharmacological profile of antidepressants and related compounds at human monoamine transportersEur. J. Pharmacol.340(2-3)249-258(1997)
3.Richelson, E., and Nelson, A.Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitroJ. Pharmacol. Exp. Ther.230(1)94-102(1984)
4.Pinder, R.M., Brogden, R.N., Speight, T.M., et al.Maprotiline: A review of its pharmacological properties and therapeutic efficacy in mental depressive statesDrugs13(5)321-352(1977) |
| | [2H3]-Maprotiline hydrochloride Preparation Products And Raw materials |
|