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| | 5,15-DIPHENYL-21H,23H-PORPHINE Basic information | | Uses |
| Product Name: | 5,15-DIPHENYL-21H,23H-PORPHINE | | Synonyms: | 5,15-DIPHENYL-21H,23H-PORPHINE;5,15-DIPHENYLPORPHINE;5, 15-BIS-(PHENYL)PORPHYRINS;5,15-Diphenylporphyrin;5,15-Bis-(phenyl)-21H,23H-porphyrins;5,15-DPP;Stat3 Inhibitor VIII, 5,15-DPP;STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem | | CAS: | 22112-89-6 | | MF: | C32H22N4 | | MW: | 462.54 | | EINECS: | | | Product Categories: | Biochemistry;Porphyrins | | Mol File: | 22112-89-6.mol |  |
| | 5,15-DIPHENYL-21H,23H-PORPHINE Chemical Properties |
| Melting point | >200℃ | | Boiling point | 912.3±65.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | ≤2mg/ml in dimethyl formamide | | form | Deep blue to deep purple solid | | color | Red to Dark blue to Black |
| WGK Germany | 3 | | HS Code | 2933.99.8290 | | HazardClass | IRRITANT |
| | 5,15-DIPHENYL-21H,23H-PORPHINE Usage And Synthesis |
| Uses | 5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical. | | Biological Activity | 5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1]. | | in vitro | 5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1]. | | references | [1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607. |
| | 5,15-DIPHENYL-21H,23H-PORPHINE Preparation Products And Raw materials |
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