1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one价格(试剂级) 上下游产品信息
| 中文名称 | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one |
|---|---|
| 中文同义词 | 化合物 T15425 |
| 英文名称 | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| 英文同义词 | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one;GSK 1702934A;GSK-1702934A,GSK1702934A;2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]- |
| CAS号 | 924377-85-5 |
| 分子式 | C22H25N3O2S |
| 分子量 | 395.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 924377-85-5.mol |
| 结构式 | ![1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one 结构式](CAS/20200401/GIF/924377-85-5.gif) |
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one 性质
| 密度 | 1.299±0.06 g/cm3(Predicted) |
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| 储存条件 | RT |
| 溶解度 | 溶于DMSO（最高50mg/ml）或乙醇（加热最高25mg/ml） |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.98±0.30(Predicted) |
| 颜色 | 白色 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one 用途与合成方法
GSK1702934A是一种选择性的 TRPC3 激动剂。GSK1702934A 通过激活 TRPC3 调节心脏收缩力和心律失常。
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TRPC3
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GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC
50
of 0.08 mM and 0.44 mM, respectively.
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes.
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes.
GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-111098 | GSK1702934A | 1 mg | 409元 | |
| 2024/08/19 | HY-111098 | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one GSK1702934A | 924377-85-5 | 5mg | 900元 |