| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CFI-401980
CAS:1610676-27-1
Purity:0 Package:100mg/RMB 25500;50mg/RMB 19800;25mg/RMB 15000
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| | CFI-401980 Basic information |
| Product Name: | CFI-401980 | | Synonyms: | CFI-401980;CFI401980,CFI 401980;Benzamide, N-cyclopropyl-2-methyl-4-[2-phenoxy-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]pyrazolo[1,5-a]-1,3,5-triazin-8-yl]- | | CAS: | 1610676-27-1 | | MF: | C28H30N6O3 | | MW: | 498.58 | | EINECS: | | | Product Categories: | | | Mol File: | 1610676-27-1.mol |  |
| | CFI-401980 Chemical Properties |
| density | 1.40±0.1 g/cm3(Predicted) | | pka | 14.46±0.20(Predicted) |
| | CFI-401980 Usage And Synthesis |
| Description | CFI-401980 a potent and selective, novel class of TTK inhibitor (TKK Ki = 0.8 nM; HCT116 GI50 = 13 nM, rat PK: oral BA =97%). CFI-401980 demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50 < 15 nM) and good rodent pharmacokinetics (oral %F 97 %). TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers. |
| | CFI-401980 Preparation Products And Raw materials |
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