6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺
中文名称 | 6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺 |
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中文同义词 | 6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺;6-氯-5-甲基-N-(喹啉-5-基)二氢吲哚-1-甲酰胺;化合物 T28680;化合物 SB-215505 |
英文名称 | SB 215505 |
英文同义词 | 6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide;6-chloro-5-methyl-N-quinolin-5-yl-2,3-dihydroindole-1-carboxamide;1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-;6-Chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide;SB 215505,SB215505 |
CAS号 | 162100-15-4 |
分子式 | C19H16ClN3O |
分子量 | 337.8 |
EINECS号 | |
相关类别 | |
Mol文件 | 162100-15-4.mol |
结构式 |
6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺 性质
沸点 | 600.9±55.0 °C(Predicted) |
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密度 | 1.385±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:~11 mg/mLat 60 °C |
酸度系数(pKa) | 12.87±0.20(Predicted) |
形态 | 固体 |
颜色 | 米白色 |
5-HT 2B Receptor 8.3 (pKi) |
5-HT 2A Receptor 6.77 (pKi) |
5-HT 2C Receptor 7.66 (pKi) |
SB-215505 is 30 fold selective for the 5-HT 2B over the 5-HT 2A receptor, and only marginally selective over the 5-HT 2C receptor.
SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2.
Animal Model: | Male Sprague-Dawley rats weighing 230-260 g |
Dosage: | 0.1, 0.3 and 1.0 mg/kg |
Administration: | IP; two doses (4 days between two doses) |
Result: | Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2. |
安全信息
WGK Germany | 3 |
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