NL-1
| 中文名称 | NL-1 |
|---|---|
| 中文同义词 | 5-(3,5-二叔丁基-4-羟基苄基)噻唑烷-2,4-二酮;化合物NL-1 |
| 英文名称 | NL 1 |
| 英文同义词 | NL 1;2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-;5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidine-2,4-dione;Inhibitor,viability,Mitochondrial Metabolism,leukemia,NL-1,CISD1,NL1,antileukemic,MitoNEET,lymphoblastic,inhibit,B-Cell,Autophagy,acute,anti-cancer,NL 1 |
| CAS号 | 188532-26-5 |
| 分子式 | C18H25NO3S |
| 分子量 | 335.46 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 188532-26-5.mol |
| 结构式 |  |
NL-1 性质
| 沸点 | 446.5±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.167±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（745.25 mM） |
| 酸度系数(pKa) | 6.34±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
MitoNEET
NL-1 (10-100 μM; 72 hours; REH, REH/Ara-C and ALL cell lines) treatment reduces the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner. NL-1 inhibits SUPB15, NALM6 with
IC
50
s of 29.48 µM, 94.26 µM, respectively. TOM1, BV173, NALM1 and JM1 all have similar
IC
50
values of around 60 µM for NL-1.
NL-1 (60 μM; 6 hours; REH, REH/Ara-C cell lines) treatment mediates autophagy, and inhibition of autophagy partially decreased NL-1-induced tumor cell death.
NL-1 pretreatment inhibits the chemotactic ability of both REH and REH/Ara-C cells to migrate towards multiple chemoattractants. The cells treated with NL1 shows a dose-dependent decrease in chemotaxis both in the REH and the REH/AraC cells.
Cell Proliferation Assay
| Cell Line: | REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines |
| Concentration: | 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner. |
Cell Autophagy Assay
| Cell Line: | REH, REH/Ara-C cell lines |
| Concentration: | 60 μM |
| Incubation Time: | 6 hours |
| Result: | Induced cell autophagy. |
NL-1 (10 mg/kg; intraperitoneal injection; daily; for 5 days; female NSG mice) treatment shows antileukemic activity in an in vivo mouse ALL model.
| Animal Model: | 10 female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Showed antileukemic activity in an in vivo mouse ALL model. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-135231 | NL-1 | 5 mg | 435元 | |
| 2024/08/19 | HY-135231 | NL-1 NL-1 | 188532-26-5 | 10mM * 1mLin DMSO | 506元 |