| Company Name: |
Shanghai Kewel Chemical Co., Ltd.
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| Tel: |
021-64609169 18901607656 |
| Email: |
greensnown@163.com |
| Products Intro: |
Product Name:Epirubicin Impurity 6（Epirubicin EP Impurity F）
CAS:57918-24-8
Purity:95+ HPLC; Package:10mg;25mg;50mg;100mg
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| | Epirubicin EP Impurity F Basic information |
| Product Name: | Epirubicin EP Impurity F | | Synonyms: | Epirubicin EP Impurity F;5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-;4’-epi-Daunorubicin;Epirubicin hydrochloride EP Impurity F(epi-Daunorubicin) | | CAS: | 57918-24-8 | | MF: | C27H29NO10 | | MW: | 527.53 | | EINECS: | | | Product Categories: | | | Mol File: | 57918-24-8.mol |  |
| | Epirubicin EP Impurity F Chemical Properties |
| Boiling point | 770.0±60.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 7.39±0.60(Predicted) | | color | Dark Red to Black | | Stability: | Light Sensitive | | InChIKey | STQGQHZAVUOBTE-WXNQWCPFNA-N | | SMILES | OC1=C2C(C3=CC=CC(OC)=C3C(=O)C2=C(O)C2[C@H](C[C@](O)(C(=O)C)CC1=2)O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](N)C1)=O |&1:18,20,28,31,33,35,r| |
| | Epirubicin EP Impurity F Usage And Synthesis |
| Uses | Daunorubicin (D194500) impurity. Daunomycin analog antitumor. | | Uses | Epirubicin EP Impurity F is an impurity of the drug Epirubicin, which is a pharmaceutical impurity standard in accordance with the European Pharmacopoeia, which can be used as a reference to analyze the quality of the drug. It is often used in the pharmaceutical industry. Epirubicin is an anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer. | | Preparation | 9.0 g of the raw material was suspended in 460 mL of purified water. Then the temperature was cooled to 0 ~ 5 °C, and 60 mL of 3.5% sodium hydroxide solution was added dropwise for 50 minutes. After the reaction was complete, the pH was adjusted to 5.0 with hydrochloric acid. The reaction solution was subsequently washed twice with 200 mL of dichloromethane and the aqueous phase was collected. 1200 mL of dichloromethane and 80 mL of methanol were added to the aqueous phase, and the pH was adjusted to 8.2 with a 0.1 mol/L sodium hydroxide solution. Collect the organic phase. The organic phase was concentrated to dryness under reduced pressure Daunorubicin7.48g.
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| | Epirubicin EP Impurity F Preparation Products And Raw materials |
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