Epirubicin EP Impurity F

Epirubicin EP Impurity F Suppliers list
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:4'-Epi-daunorubicin
CAS:57918-24-8
Remarks:BOC Sciences also provides custom synthesis services for 4'-Epi-daunorubicin.
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Epirubicin EP Impurity F
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Epirubicin EP Impurity F
CAS:57918-24-8
Purity:>=95% Package:0.5mg Remarks:BOC Sciences also provides custom synthesis services for Epirubicin EP Impurity F.
Company Name: China National Standard Pharmaceutical Corporation Limited
Tel: +8615391658522
Email: overseasales@yongstandards.com
Products Intro: Product Name:Epirubicin Impurity 6(Epirubicin EP Impurity F)
CAS:57918-24-8
Purity:0.95 Package:Vials
Company Name: QUALITY CONTROL SOLUTIONS LTD.
Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Products Intro: Product Name:Epirubicin Hydrochloride EP Impurity F(Epi-Daunorubicin)
CAS:57918-24-8
Purity:0.95 Package:10mg; 25mg;50mg;100mg Remarks:Brand: QCS; Can provide COA, hydrogen spectrum, mass spectrometry, liquid phase; Level: Pharmaceutical Impurity Standard
Epirubicin EP Impurity F Basic information
Product Name:Epirubicin EP Impurity F
Synonyms:Epirubicin EP Impurity F;5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-;4’-epi-Daunorubicin; Daunorubicin impurity 6;Epirubicin hydrochloride EP Impurity F(epi-Daunorubicin)
CAS:57918-24-8
MF:C27H29NO10
MW:527.53
EINECS:
Product Categories:
Mol File:57918-24-8.mol
Epirubicin EP Impurity F Structure
Epirubicin EP Impurity F Chemical Properties
Boiling point 770.0±60.0 °C(Predicted)
density 1.55±0.1 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form Solid
pka7.39±0.60(Predicted)
color Dark Red to Black
Stability:Light Sensitive
InChIKeySTQGQHZAVUOBTE-WXNQWCPFNA-N
SMILESOC1=C2C(C3=CC=CC(OC)=C3C(=O)C2=C(O)C2[C@H](C[C@](O)(C(=O)C)CC1=2)O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](N)C1)=O |&1:18,20,28,31,33,35,r|
Safety Information
MSDS Information
Epirubicin EP Impurity F Usage And Synthesis
UsesDaunorubicin (D194500) impurity. Daunomycin analog antitumor.
UsesEpirubicin EP Impurity F is an impurity of the drug Epirubicin, which is a pharmaceutical impurity standard in accordance with the European Pharmacopoeia, which can be used as a reference to analyze the quality of the drug. It is often used in the pharmaceutical industry. Epirubicin is an anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer.
Preparation9.0 g of the raw material was suspended in 460 mL of purified water. Then the temperature was cooled to 0 ~ 5 °C, and 60 mL of 3.5% sodium hydroxide solution was added dropwise for 50 minutes. After the reaction was complete, the pH was adjusted to 5.0 with hydrochloric acid. The reaction solution was subsequently washed twice with 200 mL of dichloromethane and the aqueous phase was collected. 1200 mL of dichloromethane and 80 mL of methanol were added to the aqueous phase, and the pH was adjusted to 8.2 with a 0.1 mol/L sodium hydroxide solution. Collect the organic phase. The organic phase was concentrated to dryness under reduced pressure Daunorubicin7.48g.
Epirubicin EP Impurity F
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