| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:XPC6444
CAS:2230144-21-3
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:XPC-6444;XPC 6444,XPC6444
CAS:2230144-21-3
Purity:98% Package:10 mg
|
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| | XPC-6444 Basic information |
| Product Name: | XPC-6444 | | Synonyms: | XPC-6444;https://pubmed.ncbi.nlm.nih.gov/34355886/;XPC 6444,XPC6444;Benzenesulfonamide, 4-[[[2-[[(1,1-dimethylethyl)methylamino]methyl]-6-fluorophenyl]methyl]amino]-2,6-difluoro-N-4-thiazolyl- | | CAS: | 2230144-21-3 | | MF: | C22H25F3N4O2S2 | | MW: | 498.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2230144-21-3.mol |  |
| | XPC-6444 Chemical Properties |
| Boiling point | 574.8±60.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (250.71 mM; Need ultrasonic) | | pka | 5.73±0.10(Predicted) | | form | Solid | | color | Off-white to yellow |
| | XPC-6444 Usage And Synthesis |
| Biological Activity | XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].
XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1].
XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1]. | | References | [1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3. |
| | XPC-6444 Preparation Products And Raw materials |
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