SB 4
| 中文名称 | SB 4 |
|---|---|
| 中文同义词 | 2-((4-溴苄基)硫代)苯并[D]恶唑;化合物SB 4;SB 4,BMP4激动剂 |
| 英文名称 | SB 4 |
| 英文同义词 | BMP signaling agonist sb4;SB 4;Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]-;SB 4 (Eticovo);2-((4-Bromobenzyl)thio)benzo[d]oxazole;Inhibitor,SMAD,bmp,cell,inhibit,BMP signaling agonist sb4,BRE-luc,BMP signaling agonist sb 4,Transforming growth factor beta receptors,PREC,BMP signaling agonist sb-4,agonist,TGF-β Receptor |
| CAS号 | 100874-08-6 |
| 分子式 | C14H10BrNOS |
| 分子量 | 320.2 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 100874-08-6.mol |
| 结构式 |  |
SB 4 性质
| 熔点 | 70-72 °C |
|---|---|
| 沸点 | 444.2±47.0 °C(Predicted) |
| 密度 | 1.57±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 0.92±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
SB 4 (Eticovo) 是一种 bone morphogenetic protein 4 (BMP4) signaling 的有效的选择性激动剂，其EC50值为74 nM。SB 4 (Eticovo) 可增强经典的BMP信号传导并激活 SMAD-1/5/9 磷酸化。
| Target | Value |
|
BMP4
(Cell-free assay) | 74 nM(EC50) |
BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions. BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4.
Western Blot Analysis
| Cell Line: | Primary mouse kidney epithelial cells (PRECs) |
| Concentration: | 0.05 μM-1 μM |
| Incubation Time: | 24 hours |
| Result: | Incresed p-SMAD-1/5/9 abundance in PRECs. |
Western Blot Analysis
| Cell Line: | BRE-Luc cells |
| Concentration: | 1 μM |
| Incubation Time: | 0min, 5 mins, 15 mins, 30 mins, 45 mins, 60 mins |
| Result: | Acted to stabilize p-SMAD-1/5/9 to enhance the transcriptional response. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-124697 | BMP signaling agonist sb4 | 5 mg | 500元 | |
| 2024/08/19 | HY-124697 | SB 4 BMP signaling agonist sb4 | 100874-08-6 | 10mM * 1mLin DMSO | 550元 |