| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:SR12343
CAS:2055101-86-3
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| Company Name: |
Jinan Jiuli Biotechnology Co. , Ltd.
|
| Tel: |
2717893647 14768611851 |
| Email: |
486064515@qq.com |
| Products Intro: |
Product Name:SR12343
CAS:2055101-86-3
Purity:98% Package:500mg；1g；5g
|
| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:SR 12343
CAS:2055101-86-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
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| | SR12343 Basic information |
| Product Name: | SR12343 | | Synonyms: | SR12343;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide | | CAS: | 2055101-86-3 | | MF: | C15H15BrClN3O | | MW: | 368.66 | | EINECS: | | | Product Categories: | | | Mol File: | 2055101-86-3.mol |  |
| | SR12343 Chemical Properties |
| Boiling point | 603.4±55.0 °C(Predicted) | | density | 1.496±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 14.86±0.46(Predicted) |
| | SR12343 Usage And Synthesis |
| Biological Activity | SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy. | | References | 1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018) |
| | SR12343 Preparation Products And Raw materials |
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