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| | INTERFERON ALFA-2A Basic information |
| Product Name: | INTERFERON ALFA-2A | | Synonyms: | Roferon;Interferon alphaA (human leukocyte protein moiety);INTERFERON ALFA-2A | | CAS: | 77907-69-8 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![INTERFERON ALFA-2A Structure]() |
| | INTERFERON ALFA-2A Chemical Properties |
| | INTERFERON ALFA-2A Usage And Synthesis |
| Uses | Antineoplastic; biological response
modifier. | | Brand name | Roferon-A (Hoffmann-LaRoche). | | Clinical Use | Interferon alfa-2a is used in the treatment of hairy cellleukemia and AIDS-related Kaposi sarcoma in selected patientsolder than 18 years of age. It is also used to treatchronic hepatitis C, and in patients with this disease, interferonalfa-2a can normalize serum alanine aminotransferase(ALT) levels, improve liver histology, and decrease viralload. The drug has a direct antiproliferative activity againsttumor cells. Modulation of the host immune response probablyplays a role in the antitumor activity of interferon alfa-2a.The interferon is supplied as a solution or as a powder forsolution. | | Drug interactions | Potentially hazardous interactions with other drugs
Aminophylline and theophylline: metabolism of
aminophylline and theophylline reduced, consider
reducing dose of aminophylline and theophylline.
Antivirals: increased risk of peripheral neuropathy
with telbivudine.
Immunosuppressants, e.g. ciclosporin, tacrolimus,
sirolimus may have an antagonistic effect | | Metabolism | Alpha-interferons are totally filtered through the glomeruli
and undergo rapid proteolytic degradation during tubular
reabsorption, rendering a negligible reappearance of intact
alfa interferon in the systemic circulation. |
| | INTERFERON ALFA-2A Preparation Products And Raw materials |
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