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| INTERFERON ALFA-2A Basic information |
Product Name: | INTERFERON ALFA-2A | Synonyms: | Roferon;Interferon alphaA (human leukocyte protein moiety);INTERFERON ALFA-2A | CAS: | 77907-69-8 | MF: | | MW: | 0 | EINECS: | | Product Categories: | | Mol File: | Mol File | ![INTERFERON ALFA-2A Structure]() |
| INTERFERON ALFA-2A Chemical Properties |
| INTERFERON ALFA-2A Usage And Synthesis |
Uses | Antineoplastic; biological response
modifier. | Brand name | Roferon-A (Hoffmann-LaRoche). | Clinical Use | Interferon alfa-2a is used in the treatment of hairy cellleukemia and AIDS-related Kaposi sarcoma in selected patientsolder than 18 years of age. It is also used to treatchronic hepatitis C, and in patients with this disease, interferonalfa-2a can normalize serum alanine aminotransferase(ALT) levels, improve liver histology, and decrease viralload. The drug has a direct antiproliferative activity againsttumor cells. Modulation of the host immune response probablyplays a role in the antitumor activity of interferon alfa-2a.The interferon is supplied as a solution or as a powder forsolution. | Drug interactions | Potentially hazardous interactions with other drugs
Aminophylline and theophylline: metabolism of
aminophylline and theophylline reduced, consider
reducing dose of aminophylline and theophylline.
Antivirals: increased risk of peripheral neuropathy
with telbivudine.
Immunosuppressants, e.g. ciclosporin, tacrolimus,
sirolimus may have an antagonistic effect | Metabolism | Alpha-interferons are totally filtered through the glomeruli
and undergo rapid proteolytic degradation during tubular
reabsorption, rendering a negligible reappearance of intact
alfa interferon in the systemic circulation. |
| INTERFERON ALFA-2A Preparation Products And Raw materials |
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