Company Name: |
Nantong Hanfang Biotechnology Co. , Ltd.
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Tel: |
18616537568 |
Email: |
hanfangpharma@126.com |
Products Intro: |
Product Name:(3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine CAS:1221973-93-8 Purity:98%+ Package:1g;5g;10g;100g; 1kg
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:BMS-933043 CAS:1221973-93-8 Package:25mg/RMB 13900;100mg/RMB 23500;50mg/RMB 18300
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(3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine manufacturers
- BMS-933043
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- $1970.00 / 25mg
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2024-10-28
- CAS:1221973-93-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine Basic information |
| (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine Chemical Properties |
Boiling point | 539.3±60.0 °C(Predicted) | density | 1.59±0.1 g/cm3(Predicted) | pka | 11.05±0.40(Predicted) |
| (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine Usage And Synthesis |
Description | BMS-933043 is a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. BMS-933043 showed potent binding affinity to native rat (Ki = 3.3 nM) and recombinant human alpha7 nicotinic acetylcholine receptors (Ki = 8.1 nM) and agonist activity in a calcium fluorescence assay (EC50 = 23.4 nM) and whole cell voltage clamp electrophysiology (EC50 = 0.14 micromolar (rat) and 0.29 micromolar (human)). BMS-933043 showed no agonist or antagonist activity at other nicotinic acetylcholine receptor subtypes and was at least 300 fold weaker at binding to and antagonizing human 5-HT3A receptors (Ki = 2,451 nM; IC50 = 8,066 nM). |
| (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine Preparation Products And Raw materials |
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