| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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Product Name:Anti-MAP Kinase (ERK-1, ERK-2)
Purity:whole antiserum Package:0.2mL Remarks:M5670
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Product Name:Anti-phospho-ERK1 (pThr202/pTyr204) and ERK2 (pThr185/pTyr187) antibody produced in rabbit
Purity:IgG fraction of antiserum, PBS suspension Remarks:affinity isolated antibody, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
Promega Corporation
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| Tel: |
1 800 356-9526 |
| Email: |
techserv@promega.com |
| Products Intro: |
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| | ANTI-MAP KINASE Basic information |
| Product Name: | ANTI-MAP KINASE | | Synonyms: | MAP KINASE (AB-2) POLYCLONAL ANTIBODY;ANTI-MAP KINASE ERK1 (339-353) (AB-2) RABBIT PAB;ANTI-MAP KINASE ERK1 (339-353) (AB-2), RAT;ANTI-MAPK;ANTI-MAP KINASE;ANTI-MITOGEN ACTIVATED PROTEIN KINASE;ANTI-ERK 1/2 PAB, RABBIT;ANTI-ERK 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-MAP KINASE Structure]() |
| | ANTI-MAP KINASE Chemical Properties |
| | ANTI-MAP KINASE Usage And Synthesis |
| Uses | Anti-MAP Kinase (ERK-1, ERK-2) antibody produced in rabbit has been used in western blot analysis at a minimum dilution of 1:40000 in rat brain extract and at 1:20000 in mouse NIH 3T3 fibroblasts. | | General Description | MAP kinase (MAPK, mitogen-activated protein kinase) is also termed as extracellular regulated protein kinase (ERK). It consists of a family of protein kinases. MAP kinase isoforms are widely expressed in the central nervous system, thymus, spleen, heart, lung, kidney, and in high levels in PC12 cells and in fibroblasts. | | Biochem/physiol Actions | Mitogen-activated protein kinase (MAPK) superfamily of enzymes is involved in widespread signalling pathways. Members of this family include the ERK1/2 (extracellular signal-regulated protein kinase, also termed p42/p44 MAPK), JNK and p38 MAPK subfamilies. These are the terminal enzymes in a signalling cascade where each kinase phosphorylates and activates the next member in the sequence. Phosphorylation of both tyrosine and threonine is essential for the full activation of all MAPKs. Several kinases participate in activation of the ERK cascade. This cascade is initiated by the small G protein Ras, which upon stimulation causes activation Raf1 kinase. Raf1 continues the transmission by activating MEK. Activated MEK appears to be the only kinase capable of specifically phosphorylating and activating ERK. ERK appears to be an important regulatory molecule, which by can phosphorylate regulatory targets in the cytosol (phospholipase A2, PLA2), translocated into and phosphorylate substrates in the nucleus (ELK1). The activation of ERK cascade mediates and regulates the signal transduction pathways in response to stress, mitogenic signals and is important in development and differentiation, learning, memory and survival. MAPK plays a crucial role in various signal transduction pathways, leading signals of growth factor and G protein coupled receptors to their intracellular targets. MAP kinase regulates several cellular processes including proliferation, differentiatio, cellular morphology and oncogenesis. |
| | ANTI-MAP KINASE Preparation Products And Raw materials |
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